Issue Summary

July 2023
Protective Effects of Sugars on Dry Proteins
Stability of Freeze-Dried IgY
Morphology of Sucrose/Mannitol Mixtures
Nebulization In-Use Studies
SC Depot Behavior of Peptide Conjugate
Atomization Effects on Spray Freeze-Drying
Mannitol-Based Antibody Lyo Formulations
ssNMR Analysis of Lyo mAb Formulations
Stabilization of mRNA Products
Polysaccharides to Stabilize Peptides
Immunogenicity of Stressed Adalimumab
Stability of an Acidic mAb
SVPs by Holographic Video Microscopy
Forced Degradation Studies of Peptides
Formulation Strategies for Peptides
Immunogenicity of Protein Aggregates
Developability Assessment of mAbs
Chemical Chaperone Effects on Aggregation
Excipient Effects on Stability of BSA
Improving the Properties of Peptide Drugs
Long-Term Stability of Infliximabs
Excipients of BMP-2 Refolding

June 2023
Studying Protein Aggregation
Surface-Induced Aggregation
Modeling PPIs and Viscosity Behavior
In-Vial Detection of Protein Unfolding
Sustained s.c. Release of scFv
Oxidation of PS 80 in Stainless Steel
Analytical Workflow and Developability
Developability Assessment of mAbs
Is There a Superior Fraction of PS 20?
Peristaltic Tubing Effects on TFF Operation
Deep Eutectic Solvents to Stabilize IgGs
Measuring Self-Association of mAbs
Predicting mAb Stability Profiles
Predicting mAb Behavior during TFF
Dynamics in Predicting mAb Properties
Polymeric Excipient and Colloidal Stability
Measuring the Stability of ADCs
Conformational Changes and LLPS
Predicting mAb Viscosity Behavior
Visible Particle Formation and Silicone Oil
Stabilization by PEGs of Different Sizes
PLGA Depots for Leuprolide Acetate

May 2023
Predicting B22 Values of mAbs
Amino-Acid Stabilized Hep B Vaccine
Comparison of Flow Imaging Instruments
Ethylene Glycol and Protein Stability
Lyophilization of mAbs
Purification and Stability of Lentivirus
Addressing Insulin Aggregation
Predicting and Control of mAb Aggregation
Hemoglobin Stabilization by DES
Dried Engineered Living Materials
Insulin Stabilization by Ionic Liquids
Transport-Induced Damage of Proteins
Large-Scale Freeze-Thaw of LDH
mAb Adsorption to Peristaltic Tubing
High Concentration Formulations
Standards for Protein-Like Visible Particles
Photo-Induced Fragmentation of a mAb
Impact of EDTA and Met on Oxidation
Stability of Tediglutide under Stress
Behavior of Proteins in Human Plasma
List of Drug Delivery Articles (11)

April 2023
High Concentration Protein Suspensions
Stabilization of Phe Ammonia Lyase
CDR-Clipping of Bevacizumab
Structural Changes in Frozen mAb Solutions
Stability of mRNA-LNPs under Stress
Buffer Effects: Mesh Nebulization of a mAb
Lamellar Particles from Glass Vials
Tubing for Peristaltic Pumping of Proteins
Silicone Oil Migration from PFS
Osmolyte Stabilization of FDH
PEG Induced Destabilization: Lactalbumin
Novel Trehalose-Based Excipients
Succinate/Sucrose Formulations of mAbs
AF4-MALLS Analysis of SP-D
Impact of Polysorbates on Flow Properties
Freezing Behavior of Mannitol Formulations
Protein Interactions during F/T Processes
Mannitol for Lyo Injectable Products
Sugar-Based Surfactants
Viscosity Behavior of Oligonucleotides
Temperature-Dependent HDX-MS

March 2023
Predicting Protein Viscosity Behavior
Oxidation Assay for Co-Formulated mAbs
FFA Production and Particle Formation
Surfactant Protection Against Agitation
Stabilization of Proteins by ILs (2)
Inhibiting Insulin Fibrillation
Ligands Inhibiting Insulin Aggregation
Surface Charge and mAb Association
Review of Protein Instability
Effect of ArgHCl on mAb Viscosity
Machine Learning Analysis of mAb SVPs
Summary of Approved Antibody Therapies
Effect of pH on LLPS
Lyo Filovirus Vaccines and Oxidation
AF4 Analysis of Liraglutide
CCI Testing of Vials Stored at -80⁰ C
Capillary Gel Electrophoresis of Proteins
Advances in Freeze-Drying
Polymorphic Changes during Drying
Transfer of a Lyophilization Process

February 2023
Monitoring Radicals in PS 80 Using EPR
Protein Particles during Peristaltic Pumping
Adsorption of Polyplexes to Tubing
Effect of Polyol Degradation
Faster s.c. Delivery
High Concentration SCIG Products
Excipient Effects on Insulin Stability
Multi-Dose VLP-Based Formulations
Soft Interactions vs. Excluded Volume
Charge Variants in a mAb
Poloxamer 188 Degradation
Poloxamer 188 as Alternative to Polysorbate
Routes of Administration for Antibodies
Improved Peptide Stability and Delivery
Long-Acting Injectable Formulations
Long-Acting Formulations for PSED
Freezing Rate Effects on Protein Stability
Needle Effects on Delivery of Viscous Solns
Effect of Air Bubbles in Ice on Proteins
Release of Silicone oil from Syringes
Albumin in Pharmaceutical Products
Injection Times for an Autoinjector

January 2023
Predicting Aggregation Using ILs
Developability Assessment of mAbs
Polysorbates vs. HP-β-CD
Use of Polysorbates in Biopharmaceuticals
Osmolytes and Molten Globule States
pH Effects on Insulin Aggregation
HSA Mitigates FFA Particle Formation
Novel Vaccine Formulation
Nose-to-Brain Peptide Delivery to CNS
Subcutaneous Delivery of Proteins
Stabilization of Bacteriophages
Fibril Inhibition by Arginine
Stability of Nivolumab
Rapid Protein Solubility Determinations
Dried Powders of anti-IL-4Rα mAb
Structural Studies of G-CSF using NMR
Photo-Oxidation by Singlet Oxygen
Host Cell Proteins in mAb HMW Species
Protein Stabilization by Alginate
Surface-Induced Aggregation of rFVIII
Novel Surfactant Protection of a mAb

December 2022
LLPS and Amyloid Aggregation
Evaluating Viscosity Reducing Excipients
Stability Studies on Trastuzumab
Effect of Acetylation on Aggregation
Artifact during nr-CE-SDS
Artifact during r-CE-SDS
Tailing in r-CE-CDS Analysis of mAbs
Lyophilized Lactobacillus Formulations
Monitoring Antibody Aggregation
Quantifying Deamidation by Mass Spec
Surface Adsorption and Nucleation Rates
Poly(Trehalose Methacrylate) as Excipient
Pallet Freezing of Biopharmaceuticals
Filter Leachables and Protein Stability
QSAR Models for mAb Solubility
pH/Crowding Effects on Protein Solubility
Preservatives and Peptide Aggregation
Fibril Heterogeneity by AFM-IR
Protein Assembly at Interfaces by AFM-IR
Aggregation of Food Proteins
Mechanical Stability of Fibrils