Introductory Course Outline

INTRODUCTION TO THE STABILIZATION AND FORMULATION OF PROTEINS

EUROPEAN CONTINUING EDUCATION COLLEGE
LONDON, UK

COURSE OUTLINE

Introduction to Protein Structure and Physical Properties

Overview of Instability Issues with Proteins

• Chemical Instability
  
• Conformational Instability (unfolding)
  
• Colloidal Instability
  
• Interfacial Instability

Protein Aggregation

• Basic Aggregation Mechanisms
• Controlling Aggregation
• Quantifying Aggregation

Rational Development of Liquid Dosage Forms

• Formulation Strategy
  
• Excipient Selection
  
• Selection of Analytical Methods

Rational Development of Dried Dosage Forms

• Formulation Strategy
• Excipient Selection

Selection of Analytical Methods